First total synthesis of eudistalbin A

First total synthesis of eudistalbin A

Eudistalbin A was isolated from marine tunicate eudistoma album and possess cytotoxic activity（ED_（50）3.2μg/mL） in vitro against the growth of KB human buccal carinoma cells.The synthetic eudistalbin A showed potent inhibitory activity against the breast carcinoma cell line MDA-231 with an IC_（50） v...

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Veröffentlicht in:Chinese chemical letters 2010-08, Vol.21 (8), p.889-891
Hauptverfasser: Zhang, Pu Yong, Wang, Jun Lei, Wan, Sheng Biao, Jiang, Tao
Format: Artikel
Sprache:eng
Schlagworte:
Eudistalbin A
Henry reaction
MDA
MTT法
Pictet–Spengler reaction
Total synthesis
β-Carboline
人力资源管理系统
全合成
化合物结构
抑制活性
核磁共振氢谱
细胞生长
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Zusammenfassung:Eudistalbin A was isolated from marine tunicate eudistoma album and possess cytotoxic activity（ED_（50）3.2μg/mL） in vitro against the growth of KB human buccal carinoma cells.The synthetic eudistalbin A showed potent inhibitory activity against the breast carcinoma cell line MDA-231 with an IC_（50） value of 2.1μmol/L using the metabolic assay MTT.All structures of new compounds were confirmed by ~1H NMR,~（13）C NMR,HRMS and optical rotation.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2010.03.017