Three antibacterial naphthoquinone analogues from cultured mycobiont of lichen Astrothelium sp

A new naphthoquinone compound named 7-hydroxyl-8-methoxyltrypethelone 3 together with two known compounds trypethelone 1 and trypethelone methyl ether 2 was isolated from cultured mycobiont of Astrothelium sp.The structures were elucidated by 1D and 2D NMR spectroscopic analysis as well as compariso...

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Veröffentlicht in:	Chinese chemical letters 2010-07, Vol.21 (7), p.842-845
Hauptverfasser:	Sun, Li Yan, Liu, Zhen Liang, Zhang, Tao, Niu, Shu Bin, Zhao, Zun Tian
Format:	Artikel
Sprache:	eng
Schlagworte:	7-Hydroxyl-8-methoxyltrypethelone Astrothelium sp Lichen MRSA Mycobiont 抗菌活性枯草芽孢杆菌核磁共振光谱萘衍生物金黄色葡萄球菌
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Zusammenfassung:	A new naphthoquinone compound named 7-hydroxyl-8-methoxyltrypethelone 3 together with two known compounds trypethelone 1 and trypethelone methyl ether 2 was isolated from cultured mycobiont of Astrothelium sp.The structures were elucidated by 1D and 2D NMR spectroscopic analysis as well as comparison with those reported in literatures.Compound 1 displayed significant antibacterial activity against Bacillus subtilis（ATCC 6633）,and showed modest antibacterial activity against Staphylococcus aureus col（MRSA）（CGMCC 1.2465）,while compounds 2 and 3 showed modest antibacterial activity against Enterococcus faecalis 850E（CGMCC 1.2135） and S.aureus col（MRSA）（CGMCC 1.2465）.
ISSN:	1001-8417 1878-5964
DOI:	10.1016/j.cclet.2010.03.024