New polyhydroxylated metabolite derived from biotransformation of diosgenin by the white-rot fungus Coriolus versicolor

Microbial transformation of diosgenin(1) was carried out with the white-rot fungus,Coriolus versicolor.A new polyhydroxyl metabolite,(25R)-spirost-5-ene-3β,7β,21-triol(2),was obtained as a result of hydroxylation.Its structure was elucidated on the basis of 1D and 2D NMR as well as HR-ESI-MS spectro...

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Veröffentlicht in:	Chinese chemical letters 2010-04, Vol.21 (4), p.446-448
Hauptverfasser:	Wu, Guang Wei, Li, Xiao Jun, Gao, Yi, Jia, Yuan, Gao, Jin Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	(25 R)-Spirost-5-ene-3β,7β,21-triol Biocatalysis Coriolus versicolor Diosgenin Microbial biotransformation
Online-Zugang:	Volltext
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Zusammenfassung:	Microbial transformation of diosgenin(1) was carried out with the white-rot fungus,Coriolus versicolor.A new polyhydroxyl metabolite,(25R)-spirost-5-ene-3β,7β,21-triol(2),was obtained as a result of hydroxylation.Its structure was elucidated on the basis of 1D and 2D NMR as well as HR-ESI-MS spectroscopic analysis.
ISSN:	1001-8417 1878-5964
DOI:	10.1016/j.cclet.2009.11.018