Highly efficient removal of allyloxycarbonyl (Alloc) function provides a practical orthogonal protective strategy for carbohydrates

Highly efficient removal of allyloxycarbonyl (Alloc) function provides a practical orthogonal protective strategy for carbohydrates

Highly efficient removal of allyloxycarbonyl (Alloc) group was achieved in the presence of CH 3COONH 4, Pd[P(C 6H 5) 3] 4, and NaBH 4 in MeOH-THF, within 5 min in almost quantitative yields (>90%, isolated yield) without affecting acetyl, benzoyl, isopropylidene, benzylidene, allyl, benzyl, benzy...

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Veröffentlicht in:Chinese chemical letters 2009-02, Vol.20 (2), p.127-130
Hauptverfasser: Zong, Guang Hui, Yan, Shi Qiang, Liang, Xiao Mei, Zhang, Jian Jun, Wang, Dao Quan, Kong, Fan Zuo
Format: Artikel
Sprache:eng
Schlagworte:
Allyloxycarbonyl group
Carbohydretes
Orthogonal protective strategy
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Zusammenfassung:Highly efficient removal of allyloxycarbonyl (Alloc) group was achieved in the presence of CH 3COONH 4, Pd[P(C 6H 5) 3] 4, and NaBH 4 in MeOH-THF, within 5 min in almost quantitative yields (>90%, isolated yield) without affecting acetyl, benzoyl, isopropylidene, benzylidene, allyl, benzyl, benzyl carbonate, or azido groups.
ISSN:1001-8417
1878-5964
DOI:10.1016/j.cclet.2008.11.002