Design, Synthesis and Biological Activity of Substituted-N-[4- (substituted-phenylsulfamoyl)phenyl]benzamide as Potential AHAS Inhibitors

Design, Synthesis and Biological Activity of Substituted-N-[4- (substituted-phenylsulfamoyl)phenyl]benzamide as Potential AHAS Inhibitors

O6; Based on the crystal structure of AHAS/sulfonylurea complex, we obtained 296compounds with low binding energy towards AHAS via virtual screening. One series of them have been synthesized. Preliminary bioassay indicated that some compounds displayed good herbicidal activity on rape and barnygrass...

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Veröffentlicht in:中国化学快报（英文版） 2006-12, Vol.17 (12), p.1555-1558
Hauptverfasser: Jian Guo WANG, Yong Jun XIAO, Yong Hong LI, Xing Hai LIU, Zheng Ming LI
Format: Artikel
Sprache:eng
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Zusammenfassung:O6; Based on the crystal structure of AHAS/sulfonylurea complex, we obtained 296compounds with low binding energy towards AHAS via virtual screening. One series of them have been synthesized. Preliminary bioassay indicated that some compounds displayed good herbicidal activity on rape and barnygrass and inhibited AHAS to some extent. This study indicated the rationality of our molecular design based on the crystal structure of target enzyme.
ISSN:1001-8417