Recurrent Patterns and Factors Involved in Node-negative Advanced Gastric Cancer

Objective: To investigate the recurrent patterns and factors involved in node-negative advanced gastric cancer after curative resection. Patients and Methods: Clinicopathological characteristics and prognostic outcomes of 310 patients who had lymph node-negative advanced gastric adenocarcinoma and r...

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Veröffentlicht in:Chinese journal of cancer research 2010-12, Vol.22 (4), p.285-290
Hauptverfasser: Liu, En-Yi, Zhong, Mei-Zuo, Liu, Cai-Gang, Huang, Jin, Liu, Wei, Zeng, Shan, Li, Bin, Lu, Jing-Chen, Li, Jian-Huang, Jiang, Hai-Rong
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Sprache:eng
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Zusammenfassung:Objective: To investigate the recurrent patterns and factors involved in node-negative advanced gastric cancer after curative resection. Patients and Methods: Clinicopathological characteristics and prognostic outcomes of 310 patients who had lymph node-negative advanced gastric adenocarcinoma and received curative resection between 2002 and 2006 were retrospectively evaluated. Results: Among the 300 patients, 15 (5.0%) had locoregional recurrence, 5 (1.7%) had lymph node recurrence, 27 (9.0%) had peritoneal seeding recurrence, and 21 (7.0%) had hematogenous metastasis. Using multivariate analysis, we found that the maximum tumor diameter (P=0.014), histological type (P=0.001) and Borrmann type (P=0.033) were independent factors predicting the locoregional recurrence. Lymph node recurrence was significantly affected by lymph node dissection (P=0.029) and lymphovascular invasion (P=0.004). Clinicopathological factors predicting the peritoneal seeding recurrence were the depth of invasion (P=0.001) and Borrmann type (P=0.002). In addition, lymphovascular invasion (P=0.013) and histological type (P=0.001) were significantly associated with hematogenous metastasis. Conclusion: Node-negative advanced gastric cancer has a high amount of peritoneal seeding and hematogenous metastasis.
ISSN:1000-9604
1993-0631
DOI:10.1007/s11670-010-0285-3