UP－REGULATION OF CYCLOOXYGENASE－2 GENE EXPRESSION CORRELATES WITH TUMOR ANGIOGENESIS IN HUMAN BREAST CANCER

UP－REGULATION OF CYCLOOXYGENASE－2 GENE EXPRESSION CORRELATES WITH TUMOR ANGIOGENESIS IN HUMAN BREAST CANCER

Objective: To study the relationship between cyclooxygenase-2 (COX-2) expression and tumor angiogenesis in human breast cancer. Methods: Archival primary breast carcinomas (n = 62), adjacent ductal carcinoma in situ (DCIS, n = 13) and DCIS alone (n = 5)were analyzed for COX-2 and VEGF expression by...

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Veröffentlicht in:Chinese journal of cancer research 2003-06, Vol.15 (2), p.149-151
1. Verfasser: 代志军 王西京 刘小旭 康华峰 姜建涛 管海涛 张淑群 薛兴欢 薛锋杰
Format: Artikel
Sprache:eng
Schlagworte:
乳腺癌
基因表达
微血管密度
环氧合酶－2
血管内皮生长因子
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Zusammenfassung:Objective: To study the relationship between cyclooxygenase-2 (COX-2) expression and tumor angiogenesis in human breast cancer. Methods: Archival primary breast carcinomas (n = 62), adjacent ductal carcinoma in situ (DCIS, n = 13) and DCIS alone (n = 5)were analyzed for COX-2 and VEGF expression by immunohistochemistry using specific monoclonal antibodies. Microvessel density (MVD) was also examined the using CD34 staining. Results: A significant correlation was found between COX-2 and VEGF expression (P
ISSN:1000-9604
1993-0631
DOI:10.1007/bf02974921