Expression of serum Dickkopf-1 in gastric cancer patients

Objective:To explore the expression and clinical significance of DKK-1 protein in patients with gastric cancers.Methods:Enzyme linked imtnuno sorbent assay was used to detect expressions of serum DKK-1 protein in 90 cases of gastric cancers,50 cases of gastric benign disease and 40 healthy cases.The dynamic change in serum DKK-1 protein of gastric cancer patients who accepted radical operation for a month was also observed.Results:The expression of serum DKK-1 protein in gastric cancer groups was significantly higher than that in gastric benign group’s(P<0.01) and in health control(P<0.01).Serum DKK 1 level was increased gradually along with the progress of the disease.Serum DKK 1 levels were significantly higher in patients at TNM staging Ⅲ and Ⅳ than patients at TNM staging Ⅰ andⅡ.Level of serum DKK-1 was related to microvascular invasion,differentiation degree and infiltration depth.Level of serum DKK-1 was significantly reduced in patients after radical surgery(P<0.01).Conclusions:The expression of serum DKK-1 protein in gastric cancer patients is increased.Level of serum DKK-1 is related to TNM staging,microvascular invasion,differentiation degree and infiltration depth.DKK-1 detection can be used as a reference index in monitoring gastric cancer progress and biological behavior.