Image Features of Retinal Astrocytic Hamartoma in a Patient with Tuberous Sclerosis Complex

Purpose： To describe the image features of retinal astrocytic hamartoma in a 35-year-old male patient with tuberous sclerosis complex （TSC）. Methods ： Fundus photography, fundus autofluorescence （FAF）, fundus fluorescein angiography （FFA）, and spectral domain optical coherence tomography （SD-OCT）were performed for this retinal astrocytic hamartoma. Results： Fundus photography showed that the retinal astrocytic hamartoma presented as a well-circumscribed, mulberry-like lesion consisting of glistening yellowish spherules of calcification. FAF demonstrated dense hyper-autofluorescence spots corresponding to retinal astrocytic hamartoma. FFA revealed leakage from dilated retinal capillaries over the hamartoma. SD-OCT indicated moth-eaten optically empty spaces and hyperreflective dots within the lesion. The lesion surface was fluctuate. Conclusion： FAF is a useful imaging modality for obtaining greater contrast between a retinal astrocytic hamartoma and the surrounding retina due to hyper-autofluorescence of calcifica- tion in the lesion. FFA is beneficial for monitoring the abnormal blood vessels in these lesions. SD-OCT is capable of visu- alization the structural details, such as the uneven surface and inner hyperreflective dots.