In vivo Implantation of Hydrophobic Acrylic Intraocular Lenses with Surface Modification

Purpose： To assess the surface properties of modified hy- drophobic acrylic intraocular lenses （IOL） implanted in rab- bits. Methods： The hydrophobic acrylic IOLs were modified with monomer vinyl pyrrolidone by surface modification technique. Phacoemulsification combined with IOL implantation was con- ducted in 9 rabbits （18 eyes）. Postoperative responses were observed by slit-lamp microscope at 3, 7, 15, 30, 90 days af- ter surgery. Results： During the early stage after IOL implantation, corneal edema and anterior chamber fibrin exudation were ob- served. The exudate fluid was almost absorbed at the 15th day postoperatively. At 7th day, the anterior chamber exudation in the modification group was significantly less severe than that in non-modification group （P〈0.05）. Posterior capsular opaci- fication occurred at 30th day after surgery and was aggravated 90 days later. IOL dislocation was seen in ,5 eyes and occlu- sion of pupil in 3 eyes. Conclusion： The hydrophobic acrylic IOLs with surface modification have improved surface properties and higher uveal biocompatibility.