Matrix Metalloproteinases Expression in Choroidal Neovascular Membranes

Purpose: To investigate the expression of matrix metalloproteinases (MMPs) in choroidal neovascular membranes with age-related macular degeneration (AMD). Methods: Seventeen choroidal neovascular membranes surgically removed from AMD patients with pars plana vitrectomy and subretinal membranes peeli...

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Veröffentlicht in:	Yanke xuebao 2004-09, Vol.20 (3), p.191-193
Hauptverfasser:	Zeng, Jun, Jiang, Deyong, Liu, Xiangping, Zhu, Xiaohua, Tang, Luosheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged AMD Bruch Membrane - enzymology Choroidal Neovascularization - enzymology Choroidal Neovascularization - etiology Choroidal Neovascularization - surgery Female Humans Macular Degeneration - complications Male Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase 9 - metabolism Middle Aged MMPs Tissue Inhibitor of Metalloproteinases - metabolism Vitrectomy 基因表达脉络膜血管膜金属蛋白质
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Zusammenfassung:	Purpose: To investigate the expression of matrix metalloproteinases (MMPs) in choroidal neovascular membranes with age-related macular degeneration (AMD). Methods: Seventeen choroidal neovascular membranes surgically removed from AMD patients with pars plana vitrectomy and subretinal membranes peeling were investigated. The expression of MMP-2 and MMP-9 was determined with immunohistochemical technique. Results: Immunohistochemistry staining in choroidal neovascular membranes for MMP-2 and MMP-9 was observed in 17 specimens. There was no detective of MMP-2 and MMP-9 in normal retinas. Conclusions : MMP-2 and MMP-9 were found in choroidal neovascular membranes, maydegrade the Bruch membrane and be associated with the perforation of new vessels into Bruch membrane, involving a basic pathogenic process of AMD. Eye Science 2004;20:191-193.
ISSN:	1000-4432