The Study of Relationships between the Damage of Visual Function and Hemorrheology,Ocular Rheog-raphy,as well as Other Related Factors in Patients with Primary Open Angle Glaucoma (POAG)

Researches of glaucoma visual function damage,hemorrheololgy,ocular rheog-raphy and other related multiplex factors,with computed multifactorial stepwise regresion analysis,indicate that the elevation of intraocular pressure (lOP) is not the only factor to induce visual impairment.POAG patients are shown to have markedly reduced diastolic purfussion pressure in ophthalmic artery,besides prolonged filling time of the retinal artery and vein,diminished erythrocyte deformability and increased platelet adhesion rate.The characterility of ocular rheographic changes in POAG patients of controlled lOP suggest that the abnormal chan-ges of hemorrheololgy be responsible for the damage of visual function.The abnormal changes of plasma viscosity,blood apparent viscosity,blood viscoelasticity,hematocrit,mean red cell volume etc could be found in addition to the reduction of PO2,SO2％ and trace elements (Cr,Zn,Mg,Fe) in patients with POAG.Computed multiply stepwise regression analysis and Bayes dis-crimination were made among the deteriorate rate of quantitative visual field and 28 factors from the combined investigation.Only the hemorrheologicai index could be introduced into the mul-tiply regression equations.The rnore the damage of visual function in POAG patients,the more accurate the discriminatory effect.Based upon the results,and the reports of articles published as well as the search of 1982-1989 Compact Combridge MEDLINE Medical data base,the new clinical concept could be presented that POAG might belong to the scope of blood hypervis-cosity syndromes.When lOP elevation and the decrease of ocular artery pressure existed,the damage of visual function in POAG patients should be deteriorated.Eye Science 1993;9:3-11.