Changes in Behavior and Amino Acid Neurotransmitters in the Brain of Rats with Seizure Induced by IL-1β or IL-6

To explore the mechanism of epilepsy induced by IL-1β and 1L-6, the changes of glutamie acid (Glu) and GABA immunoreaetion in the cerebral cortex and hippoeampus of rats with seizure induced by IL-1β or IL-6 were studied. Rats were randomly divided into 3 groups: control group (intraeerebroventrieular injection (iev) of NS), IL-1β group (iev injection of IL-1β) and IL-6 group (i. e. v. injection of IL-6). 120 min after the iev injection of reagents of IL-1β or IL-6, behavioral changes were observed and Glu and GABA in the cerebral cortex and hippoeampus were examined by means of immunohistoehemistry. Our results showed that no seizure developed in the control group, while moderate seizure was observed in IL-1β group and IL-6 group. Compared with the controls, the immunoreaetion of Glu was significantly increased, while GABA was obviously decreased in IL-1β group and IL-6 group after 120 min. Our study suggested that the IL-1β and IL-6 might promote and induce epilepsy by increasing Glu and decreasing GABA in the cerebral cortex and hippoeampus.