Advances in research on preparation of canine femoral head necrosis by liquid nitrogen freezing

Femoral head necrosis has become one of the common and difficult diseases of orthopedics, and its incidence is now on a clear upward trend. If the effective treatment is not carried out in the early stage, it will lead to the collapse of local necrotic bone, which will seriously endanger human health and even cause it to lose its ability to work and self-care, and eventually cause disability. Its treatment program has not made great breakthroughs at home and abroad. However, an animal model that fully reflects human osteonecrosis has not yet been fully replicated. Therefore, it is necessary to establish an animal model that can conform to the pathological evolution process of avascular necrosis of human femoral head. It is necessary to study the preparation of liquid nitrogen-type ONFH model by reviewing relevant literatures at home and abroad in recent years.