Analysis of inflammation, antioxidant, insulin resistance and bone metabolism in patients with chronic periodontitis

Objective:To investigate the changes and clinical significance of inflammation, antioxidation, insulin resistance and bone metabolism in patients with chronic periodontitis.Methods: 50 patients with chronic periodontitis treated in our hospital from January 2017 to March 2018 were selected as the observation group and 50 cases of periodontal health were selected as control group. The expression levels of related indicators of inflammation [including macrophage migration inhibitory factor (MIF), monocyte chemoattractant protein-1 (MCP-1), granulocyte-macrophage colony-stimulating factor (GM-CSF)], antioxidant [including nitric oxide (NO) and nitric oxide synthase (NOS)], insulin resistance [including adiponectin, leptin (LEP)] and bone metabolism [including visfatin and calcitonin gene-related peptide (CGRP)] in the two groups were observed and compared.Results: Except for the levels of adiponectin [(3.03±0.40) ng/L] and CGRP [(32.40±12.61) μg/L] in the observation group [(5.33±0.63) ng/L and (49.84±13.36) μg/L, respectively] were significantly lower than those in the control group (P