Efficacy of neoadjuvant chemotherapy in the treatment of locally advanced cervical cancer and safety evaluation

Objective: To explore the efficacy of different neoadjuvant chemotherapy (NACT ) i n t h e treatment of locally advanced cervical cancer (LACC) and safety evaluation. Methods: A total of 68 patients with LACC who were admitted in our hospital from April;2015 to August;2016 were included in the study and divided into the observation group (n=34) and the control group (n=34) according to different chemotherapy regimens. The patients in the observation group were given docetaxel and oxaliplatin (DTX+OXA);while the patients in the control group were given TAX and DDP. 21 d-treatment was regarded as one course;for 2 courses. After treatment;the patients in the two groups were given laparoscopic extensive hysterectomy;pelvic lymph node dissection;and abdominal aortic lymph node sampling. The short-term efficacy and adverse reactions in the two groups were observed. Pathological evaluation of postoperative specimens in the two groups was performed. The peripheral blood T lymphocyte subsets and NK cell in the two groups were detected and compared. Results: ORR and DCR in the observation group were 47.09% and 91.18%;respectively;while those in the control group were 44.12% and 85.29%;respectively;and the comparison between the two groups was not statistically significant. When compared with before treatment;CD4+;CD8+;and NK cell after treatment in the two groups were significantly reduced;while CD4+/CD8+ was significantly increased;but the comparison between the two groups was not statistically significant. It was proved by the postoperative pathology that the comparison of PCR;PR1;and PR2 between the two groups was not statistically significant. Meanwhile;the comparison of cervical infiltration depth;surgical incision;parametrial infiltration;and pelvic lymph node metastasis between the two groups was not statistically significant. The proportion of alopecia;gastrointestinal reaction;and renal toxicity in the observation was significantly lower than that in the control group;but the proportion of peripheral neurotoxicity was significantly higher than that in the control group. Conclusions: Before laparoscopy;the short-term efficacy of DTX+OXA and TAX+DDP in the treatment of LACC is equal;but DTX+OXA has a lower toxic reaction;and higher safety;therefore;it deserves to be recommended in the clinic.