Nerve cell apoptosis in patients with post-stroke depression

Objective:To study the relationship of serum thyroid-stimulating hormone (TSH) levels with neurotransmitters, neurotrophic state and nerve cell apoptosis in patients with post-stroke depression (PSD).Methods: Patients with ischemic stroke who were treated in our hospital between June 2014 and October 2016 were selected, and according to the HAMD-17 score at 14 days after onset, the enrolled patients were divided into into the post-stroke depression group (PSD group) and stroke group (PS group). Serum levels of TSH, neurotransmitters, neurotrophic cytokines and apoptotic molecules were detected.Results: Serum TSH, 5-HT, NE, DA, BDNF and NGF levels of PSD group were significantly lower than those of PS group while Bax, FasL, Fas and Caspase-3 levels were significantly higher than those of PS group; 5-HT, NE, DA, BDNF and NGF levels of PSD group of patients with low TSH were significantly lower than those of PSD group of patients with normal TSH while Bax, FasL, Fas and Caspase-3 levels were significantly higher than those of PSD group of patients with normal TSH.Conclusion:The decrease of serum TSH level in patients with PSD can affect neurotransmitters, neurotrophic state and nerve cell apoptosis.