Assessment of platelet-leukocyte aggregation content in serum of patients with acute cerebral infarction and its correlation with atherosclerosis

Objective:To study the platelet-leukocyte aggregation content in serum of patients with acute cerebral infarction and its correlation with atherosclerosis.Methods: Patients with acute cerebral infarction treated in our hospital between May 2012 and October 2015 were selected as the cerebral infarction group of the study, and healthy volunteers receiving physical examination in our hospital during the same period were selected as the control group of the study. The serum levels of platelet-leukocyte aggregation, proteases and cytokines were determined.Results:Platelet-leukocyte aggregation, platelet-monocyte aggregation, platelet-granulocyte aggregation and platelet-lymphocyte aggregation content in serum of cerebral infarction group were significantly higher than those of control group; platelet-leukocyte aggregation and platelet-monocyte aggregation content in serum of vulnerable plaque group and stable plaque group were higher than those of no plaque group, and platelet-leukocyte aggregation and platelet-monocyte aggregation content in serum of vulnerable plaque group were higher than those of stable plaque group; platelet-granulocyte aggregation and platelet-lymphocyte aggregation content in serum were not significantly different among vulnerable plaque group, stable plaque group and no plaque group. The higher the platelet-monocyte aggregation content, the higher the MMP7, MMP9, CatK, MCP-1, VE-cadherin, CD40, CD40L and CXCL16 content, and the lower the PON1 and PON3 content in serum of cerebral infarction group.Conclusions:Platelet-leukocyte aggregation content significantly increases in serum of patients with acute cerebral infarction, aggregation formed by monocyte of leukocytes and platelet is associated with the carotid plaque formation and the change in nature, but the aggregation formed by lymphocyte and platelet as well as granulocyte and platelet are not involved in the carotid plaque formation and the change in nature.