Effect of alginate dressing and petrolatum gauze on wound healing and related molecule expression in scar-skin donor site

Objective:To study the effect of alginate dressing and petrolatum gauze on burned and scalded skin wound healing and relevant molecule expression.Methods: A total of 64 cases of patients with large-area burn who received skin grafting treatment in our hospital from May 2010 to October 2015 were selected for study and randomly divided into alginate group and petrolatum group who received different dressing for donor site dressing change. The wound healing was observed, and mRNA levels and protein levels of TGF-β1, bFGF, VEGF and EGF in wound tissue were determined.Results:The average wound healing time (12.6±1.8 vs. 17.2±2.1 d) of alginate group was significantly shorter than that of petrolatum group, and the wound healing conditions 3 d, 6 d and 9 d after dressing change were better than those of petrolatum group; mRNA levels and protein levels of TGF-β1, bFGF, VEGF and EGF in wound tissue of alginate group were significantly higher than those of petrolatum group.Conclusion: Alginate dressing can promote the wound healing in scar-skin donor site, and is conducive to the granulation tissue formation, angiogenesis and epithelization process.