18F-PBR06 PET/CT imaging of inflammation and differentiation of lung cancer in mice

18F-PBR06 PET/CT imaging of inflammation and differentiation of lung cancer in mice

The present study explored the 18-kDa translocator protein radioligand 18 F-PBR06 as a PET imaging biomarker for diagnosis of inflammation and compared it with 18 F-FDG for differentiation of inflammation and lung tumors in animals. 18 F-PBR06 was synthesized with an average decay-corrected radioche...

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Veröffentlicht in:Nuclear science and techniques 2019-05, Vol.30 (5), p.122-129, Article 83
Hauptverfasser: Zhang, He, Tan, Hui, Mao, Wu-Jian, Zhou, Jun, Fu, Zhe-Quan, Hu, Yan, Xiao, Jie, Lin, Qing-Yu, Shi, Hong-Cheng, Cheng, Deng-Feng
Format: Artikel
Sprache:eng
Schlagworte:
Energy
Hadrons
Heavy Ions
Nuclear Energy
Nuclear Physics
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Zusammenfassung:The present study explored the 18-kDa translocator protein radioligand 18 F-PBR06 as a PET imaging biomarker for diagnosis of inflammation and compared it with 18 F-FDG for differentiation of inflammation and lung tumors in animals. 18 F-PBR06 was synthesized with an average decay-corrected radiochemical yield of 30–40% (end of synthesis, EOS), and the radiochemical purity was greater than 99%. The inflammation-to-blood ratio of 18 F-PBR06 (3.53 ± 0.26) was higher than the tumor-to-blood ratio (1.77 ± 0.35) ( P  
ISSN:1001-8042
2210-3147
DOI:10.1007/s41365-019-0597-z