Enhanced Survivin siRNA Delivery Using Cationic Liposome Incorporating Fatty Acid-modified Polyethylenimine
We described a novel approach for survivin fatty acid-modified polyethylenimine. A linoleic acid siRNA cellular delivery via a cationic liposome incorporating derivative of branched polyethylenimine（PEI, Mw=25 kDa）, PEI-LA, was synthesized and incorporated into the liposome. The properties of the li...
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| Veröffentlicht in: | Chemical research in Chinese universities 2015-06, Vol.31 (3), p.401-405 |
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| creator | Yang, Shuang Guo, Zhihua Yang, Xuewei Xie, Jing Lee, Robert J. Jiang, Dan Teng, Lesheng |
| description | We described a novel approach for survivin fatty acid-modified polyethylenimine. A linoleic acid siRNA cellular delivery via a cationic liposome incorporating derivative of branched polyethylenimine（PEI, Mw=25 kDa）, PEI-LA, was synthesized and incorporated into the liposome. The properties of the liposome, cytotoxicity, cellular uptake of cancer cells for survivin siRNA, survivin protein downregulation levels were investigated. PEl-modified liposome showed a lower cytotoxicity and delivered survivin siRNA into HeLa cells and A549 cells efficiently com- pared with PEI-25kDa. |
| doi_str_mv | 10.1007/s40242-015-5060-z |
| format | Article |
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A linoleic acid siRNA cellular delivery via a cationic liposome incorporating derivative of branched polyethylenimine（PEI, Mw=25 kDa）, PEI-LA, was synthesized and incorporated into the liposome. The properties of the liposome, cytotoxicity, cellular uptake of cancer cells for survivin siRNA, survivin protein downregulation levels were investigated. 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PEl-modified liposome showed a lower cytotoxicity and delivered survivin siRNA into HeLa cells and A549 cells efficiently com- pared with PEI-25kDa.</description><subject>Analytical Chemistry</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Inorganic Chemistry</subject><subject>Organic Chemistry</subject><subject>Physical Chemistry</subject><subject>siRNA</subject><subject>交付使用</subject><subject>存活</subject><subject>细胞毒性</subject><subject>聚乙烯亚胺</subject><subject>脂肪</subject><subject>酸改性</subject><subject>阳离子脂质体</subject><issn>1005-9040</issn><issn>2210-3171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp9kUtPIzEQhK0VSBseP2BvI24cvLTtsSdzjMJjI0WAduFsOR574mxiB3sSMvn1GAXBjVMfqr4udTVCvwj8JgDVVSqBlhQD4ZiDALz_gQaUEsCMVOQIDbKJ4xpK-IlOUloAsFqIcoD-3_i58to0xb9N3Lqt80Vyf-9HxbVZuq2JffGcnG-Lsepc8E4XU7cOKaxMMfE6xHWIWcj6req6vhhp1-BVaJx1eeNjWPamm_dL493KeXOGjq1aJnP-MU_R8-3N0_gPnj7cTcajKdasrDtsORCmZ41m3FaaVFoJVZvKCM1nTJWigiFYmw8gDaiSW9qIoa3tbFhR1ShO2Sm6POx9Vd4q38pF2ESfE2Xb7HbzXb-guSdgQET2koNXx5BSNFauo1up2EsC8r1ZeWhWZkK-Nyv3maEHJmWvb038CvgOuvgImgffvmTuMyk_oq6AC8LeAN6vibw</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Yang, Shuang</creator><creator>Guo, Zhihua</creator><creator>Yang, Xuewei</creator><creator>Xie, Jing</creator><creator>Lee, Robert J.</creator><creator>Jiang, Dan</creator><creator>Teng, Lesheng</creator><general>Jilin University and The Editorial Department of Chemical Research in Chinese Universities</general><general>College of Pharmacy, The Ohio State University, Columbus 43210, USA</general><general>College of Life Sciences, Jilin University, Changchun 130012, P.R.China%College of Life Sciences, Jilin University, Changchun 130012, P.R.China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>~WA</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20150601</creationdate><title>Enhanced Survivin siRNA Delivery Using Cationic Liposome Incorporating Fatty Acid-modified Polyethylenimine</title><author>Yang, Shuang ; Guo, Zhihua ; Yang, Xuewei ; Xie, Jing ; Lee, Robert J. ; Jiang, Dan ; Teng, Lesheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-f5013cbdc35f7c17ca6a9e7e6c5b3a467080ff0391d0a45f2d68f9fb872ada523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Analytical Chemistry</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Inorganic Chemistry</topic><topic>Organic Chemistry</topic><topic>Physical Chemistry</topic><topic>siRNA</topic><topic>交付使用</topic><topic>存活</topic><topic>细胞毒性</topic><topic>聚乙烯亚胺</topic><topic>脂肪</topic><topic>酸改性</topic><topic>阳离子脂质体</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Shuang</creatorcontrib><creatorcontrib>Guo, Zhihua</creatorcontrib><creatorcontrib>Yang, Xuewei</creatorcontrib><creatorcontrib>Xie, Jing</creatorcontrib><creatorcontrib>Lee, Robert J.</creatorcontrib><creatorcontrib>Jiang, Dan</creatorcontrib><creatorcontrib>Teng, Lesheng</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>CrossRef</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Chemical research in Chinese universities</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Shuang</au><au>Guo, Zhihua</au><au>Yang, Xuewei</au><au>Xie, Jing</au><au>Lee, Robert J.</au><au>Jiang, Dan</au><au>Teng, Lesheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhanced Survivin siRNA Delivery Using Cationic Liposome Incorporating Fatty Acid-modified Polyethylenimine</atitle><jtitle>Chemical research in Chinese universities</jtitle><stitle>Chem. 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| ispartof | Chemical research in Chinese universities, 2015-06, Vol.31 (3), p.401-405 |
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| source | SpringerNature Journals |
| subjects | Analytical Chemistry Chemistry Chemistry and Materials Science Chemistry/Food Science Inorganic Chemistry Organic Chemistry Physical Chemistry siRNA 交付使用 存活 细胞毒性 聚乙烯亚胺 脂肪 酸改性 阳离子脂质体 |
| title | Enhanced Survivin siRNA Delivery Using Cationic Liposome Incorporating Fatty Acid-modified Polyethylenimine |
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