Enhanced Survivin siRNA Delivery Using Cationic Liposome Incorporating Fatty Acid-modified Polyethylenimine

Enhanced Survivin siRNA Delivery Using Cationic Liposome Incorporating Fatty Acid-modified Polyethylenimine

We described a novel approach for survivin fatty acid-modified polyethylenimine. A linoleic acid siRNA cellular delivery via a cationic liposome incorporating derivative of branched polyethylenimine（PEI, Mw=25 kDa）, PEI-LA, was synthesized and incorporated into the liposome. The properties of the li...

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Veröffentlicht in:Chemical research in Chinese universities 2015-06, Vol.31 (3), p.401-405
Hauptverfasser: Yang, Shuang, Guo, Zhihua, Yang, Xuewei, Xie, Jing, Lee, Robert J., Jiang, Dan, Teng, Lesheng
Format: Artikel
Sprache:eng
Schlagworte:
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Inorganic Chemistry
Organic Chemistry
Physical Chemistry
siRNA
交付使用
存活
细胞毒性
聚乙烯亚胺
脂肪
酸改性
阳离子脂质体
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Zusammenfassung:We described a novel approach for survivin fatty acid-modified polyethylenimine. A linoleic acid siRNA cellular delivery via a cationic liposome incorporating derivative of branched polyethylenimine（PEI, Mw=25 kDa）, PEI-LA, was synthesized and incorporated into the liposome. The properties of the liposome, cytotoxicity, cellular uptake of cancer cells for survivin siRNA, survivin protein downregulation levels were investigated. PEl-modified liposome showed a lower cytotoxicity and delivered survivin siRNA into HeLa cells and A549 cells efficiently com- pared with PEI-25kDa.
ISSN:1005-9040
2210-3171
DOI:10.1007/s40242-015-5060-z