LC-MS/MS Method for the Quantitation of Cefotetan in Human Plasma and Its Application to Pharmacokinetic Study

A rapid and sensitive liquid chromatography-tandem mass spectrometry（LC-MS/MS） method for the de- termination of cefotetan in human plasma was developed and validated. After the protein precipitation of sample with acetonitrile, the analyte and internal standard（IS）, tramadol, were separated on a Zo...

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Veröffentlicht in:	Chemical research in Chinese universities 2014-12, Vol.30 (6), p.900-904
Hauptverfasser:	Shi, Meiyun, Yin, Lei, Cai, Lanlan, Wang, Can, Liu, Xidong, Zhao, Sen, Sun, Yantong, Fawcett, Paul J., Zhao, Limei, Yang, Yan, Gu, Jingkai
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical Chemistry Chemistry Chemistry and Materials Science Chemistry/Food Science Inorganic Chemistry LC-MS Organic Chemistry Physical Chemistry S方法 人血浆 头孢 应用 相对标准偏差 药代动力学 蛋白质沉淀
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