Stereoselective synthesis of (R)-salmeterol via asymmetric cyanohydrin reaction

Stereoselective synthesis of (R)-salmeterol via asymmetric cyanohydrin reaction

The authors described a short and highly enantioselective route to ( R )-salmeterol involving asymmetric synthesis of cyanohydrin followed by nucleophilic substitution with 6-(4-phenylbutoxy) hexyl methanesulfonate.

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Veröffentlicht in:Chemical research in Chinese universities 2014-10, Vol.30 (5), p.770-773
Hauptverfasser: Li, Wei, Huang, Hai, Jin, Xiaodong, Liu, Yujian, Xu, Chaohang, Zhu, Hongjun
Format: Artikel
Sprache:eng
Schlagworte:
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Inorganic Chemistry
Organic Chemistry
Physical Chemistry
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Zusammenfassung:The authors described a short and highly enantioselective route to ( R )-salmeterol involving asymmetric synthesis of cyanohydrin followed by nucleophilic substitution with 6-(4-phenylbutoxy) hexyl methanesulfonate.
ISSN:1005-9040
2210-3171
DOI:10.1007/s40242-014-4073-3