One Pot, Multi-component Synthesis of 3-[(4-Aryl-thiazol-2-yl)-hydrazono]-1,3-dihydro-indole-2-one

A series of 3-[(4-phenyl-thiazol-2-yl)-hydrazono]-1,3-dihydro-indole-2-one(4a-4g) and 3-{[4-(2-oxo2H-chromen-3-yl)-thiazol-2-yl]-hydrazono}-1,3-dihydro-indol-2-one(6a-6d) has been prepared in a one-step procedure from condensation reaction of isatin(1),thiosemicarbazide(2) and bromoacetophenones(3)/...

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Veröffentlicht in:Chemical research in Chinese universities 2014-08, Vol.30 (4), p.601-604
Hauptverfasser: Aychiluhim, Tewodros Birhanu, Vedula, Rajeswar Rao
Format: Artikel
Sprache:eng
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Zusammenfassung:A series of 3-[(4-phenyl-thiazol-2-yl)-hydrazono]-1,3-dihydro-indole-2-one(4a-4g) and 3-{[4-(2-oxo2H-chromen-3-yl)-thiazol-2-yl]-hydrazono}-1,3-dihydro-indol-2-one(6a-6d) has been prepared in a one-step procedure from condensation reaction of isatin(1),thiosemicarbazide(2) and bromoacetophenones(3)/or 3-(2-bromoacetyl)coumarins(4).The method provides a simple and efficient route to prepare the compounds in good yields and in a short experimental time as compared to its stepwise procedure.
ISSN:1005-9040
2210-3171
DOI:10.1007/s40242-014-4036-8