Synthesis and Release Behavior of a Hybrid of Camptothecin Intercalated Dodecyl Sulfate Modified Layered Double Hydroxide

The intercalation of a non-ionic and poorly water-soluble drug,camptothecin（CPT）,into dodecyl sulfate （DS） modified layered double hydroxide（LDH） was carried out via a secondary intercalation method to obtain a CPT-DS-LDH hybrid.The in vitro CPT release eFxaminations from the hybrid show that the hybrid can well control the release of CPT,which indicates that the hybrid is a potential drug controlled-release system.Moreover,the intercalation kinetics of CPT into the DS modified LDH fits for the pseudo-second-order model.And the release kinetic process of CPT from the CPT-DS-LDH hybrid at pH=4.8 can be described with pseudo-first-order model,while that at pH=7.2 can be described with both pseudo-first-order model and pseudo-second-order model.Meanwhile,the release mechanism of CPT from the CPT-DS-LDH hybrid was discussed.