In vitro Degradation and Biocompatibility of Ca-P Coated Magnesium Alloy
Calcium-phosphate compounds（Ca-P） coating was prepared on an Mg-A1 alloy（AZ60）. Biodegradation of Ca-P coated magnesium alloy was evaluated in simulated body fluid（SBF） by examining the changes in magnesium ion concentration and pH value, which indicated that the Ca-P coating on magnesium alloy stro...
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| Veröffentlicht in: | Chemical research in Chinese universities 2013-04, Vol.29 (2), p.285-289 |
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| creator | Xiao, Xing Zhu, Qing-san Su, Ying-chao Li, Guang-yu |
| description | Calcium-phosphate compounds（Ca-P） coating was prepared on an Mg-A1 alloy（AZ60）. Biodegradation of Ca-P coated magnesium alloy was evaluated in simulated body fluid（SBF） by examining the changes in magnesium ion concentration and pH value, which indicated that the Ca-P coating on magnesium alloy strongly affected the cor- rosion of magnesium alloy. Osteoblast MC3T3-E1 cells were utilized to investigate the cellular eytocompatibility. The cytocompatibility was measured by carrying out a series of tests, such as cholecystokinin-octapeptide（CCK-8） test, alkaline phosphatase activity（ALP） test, cellular morphology of hematoxylin-eosin（HE） staining and the induc- tion of apoptosis. It was found that the cell function showed better in the Ca-P coated Mg-alloy extract than in the uncoated magnesium alloy extract. In summary, the results indicate that the Ca-P coating can improve the corrosion resistance of magnesium alloy and elevate cellular proliferation and differentiation of osteoblast MC3T3-E1 cells. |
| doi_str_mv | 10.1007/s40242-013-2314-5 |
| format | Article |
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Biodegradation of Ca-P coated magnesium alloy was evaluated in simulated body fluid（SBF） by examining the changes in magnesium ion concentration and pH value, which indicated that the Ca-P coating on magnesium alloy strongly affected the cor- rosion of magnesium alloy. Osteoblast MC3T3-E1 cells were utilized to investigate the cellular eytocompatibility. The cytocompatibility was measured by carrying out a series of tests, such as cholecystokinin-octapeptide（CCK-8） test, alkaline phosphatase activity（ALP） test, cellular morphology of hematoxylin-eosin（HE） staining and the induc- tion of apoptosis. It was found that the cell function showed better in the Ca-P coated Mg-alloy extract than in the uncoated magnesium alloy extract. In summary, the results indicate that the Ca-P coating can improve the corrosion resistance of magnesium alloy and elevate cellular proliferation and differentiation of osteoblast MC3T3-E1 cells.</description><identifier>ISSN: 1005-9040</identifier><identifier>EISSN: 2210-3171</identifier><identifier>DOI: 10.1007/s40242-013-2314-5</identifier><language>eng</language><publisher>Heidelberg: Jilin University and The Editorial Department of Chemical Research in Chinese Universities</publisher><subject>Analytical Chemistry ; Chemistry ; Chemistry and Materials Science ; Chemistry/Food Science ; Inorganic Chemistry ; Mg-Al合金 ; Organic Chemistry ; Physical Chemistry ; 体外降解 ; 八肽胆囊收缩素 ; 涂层制备 ; 生物相容性 ; 碱性磷酸酶活性 ; 钙化合物 ; 镁合金</subject><ispartof>Chemical research in Chinese universities, 2013-04, Vol.29 (2), p.285-289</ispartof><rights>Jilin University, The Editorial Department of Chemical Research in Chinese Universities and Springer-Verlag GmbH 2013</rights><rights>Copyright © Wanfang Data Co. 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Res. Chin. Univ</addtitle><addtitle>Chemical Research in Chinese University</addtitle><description>Calcium-phosphate compounds（Ca-P） coating was prepared on an Mg-A1 alloy（AZ60）. Biodegradation of Ca-P coated magnesium alloy was evaluated in simulated body fluid（SBF） by examining the changes in magnesium ion concentration and pH value, which indicated that the Ca-P coating on magnesium alloy strongly affected the cor- rosion of magnesium alloy. Osteoblast MC3T3-E1 cells were utilized to investigate the cellular eytocompatibility. The cytocompatibility was measured by carrying out a series of tests, such as cholecystokinin-octapeptide（CCK-8） test, alkaline phosphatase activity（ALP） test, cellular morphology of hematoxylin-eosin（HE） staining and the induc- tion of apoptosis. It was found that the cell function showed better in the Ca-P coated Mg-alloy extract than in the uncoated magnesium alloy extract. In summary, the results indicate that the Ca-P coating can improve the corrosion resistance of magnesium alloy and elevate cellular proliferation and differentiation of osteoblast MC3T3-E1 cells.</description><subject>Analytical Chemistry</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemistry/Food Science</subject><subject>Inorganic Chemistry</subject><subject>Mg-Al合金</subject><subject>Organic Chemistry</subject><subject>Physical Chemistry</subject><subject>体外降解</subject><subject>八肽胆囊收缩素</subject><subject>涂层制备</subject><subject>生物相容性</subject><subject>碱性磷酸酶活性</subject><subject>钙化合物</subject><subject>镁合金</subject><issn>1005-9040</issn><issn>2210-3171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9kMtOwzAURC0EEqXwAezMkoXBryTNspRHKxXBAtbWdRKnqVK72AGav8dVKtihu7jS6MyMNAhdMnrDKM1ug6RcckKZIFwwSZIjNOKcUSJYxo7RKEIJyamkp-gshDWlIk9TOULzhcVfTecdvq9qDyV0jbMYbInvGle4zTYKummbrsfO4BmQVzxz0FUlfobaVqH53OBp27r-HJ0YaEN1cfhj9P748Dabk-XL02I2XZJCyElHWM41gMmkNKnUPNe6KIsMiihOCsZ0Ajk3meaQsYQKzoCllclzCZpCKrJEjNH1kPsN1oCt1dp9ehsbVV3udqtdv-ZxBMrjRZYNbOFdCL4yauubDfheMar2s6lhNhUdaj-b2ufzwRMia-vK_xX8Z7o6FK2crT-i77dJJiLLhUjED4R_eow</recordid><startdate>20130401</startdate><enddate>20130401</enddate><creator>Xiao, Xing</creator><creator>Zhu, Qing-san</creator><creator>Su, Ying-chao</creator><creator>Li, Guang-yu</creator><general>Jilin University and The Editorial Department of Chemical Research in Chinese Universities</general><general>The First Hospital of Jilin University, Changchun 130021, P.R.China%College of Materials Science and Engineering, Jilin University, Changchun 130022, P.R.China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>~WA</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20130401</creationdate><title>In vitro Degradation and Biocompatibility of Ca-P Coated Magnesium Alloy</title><author>Xiao, Xing ; Zhu, Qing-san ; Su, Ying-chao ; Li, Guang-yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-192baaf744f64b29bbcdc7acbaa8c11b5a92f7b2a7150321a16ef994ab0a63753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Analytical Chemistry</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Chemistry/Food Science</topic><topic>Inorganic Chemistry</topic><topic>Mg-Al合金</topic><topic>Organic Chemistry</topic><topic>Physical Chemistry</topic><topic>体外降解</topic><topic>八肽胆囊收缩素</topic><topic>涂层制备</topic><topic>生物相容性</topic><topic>碱性磷酸酶活性</topic><topic>钙化合物</topic><topic>镁合金</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xiao, Xing</creatorcontrib><creatorcontrib>Zhu, Qing-san</creatorcontrib><creatorcontrib>Su, Ying-chao</creatorcontrib><creatorcontrib>Li, Guang-yu</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>CrossRef</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>Chemical research in Chinese universities</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiao, Xing</au><au>Zhu, Qing-san</au><au>Su, Ying-chao</au><au>Li, Guang-yu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro Degradation and Biocompatibility of Ca-P Coated Magnesium Alloy</atitle><jtitle>Chemical research in Chinese universities</jtitle><stitle>Chem. 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It was found that the cell function showed better in the Ca-P coated Mg-alloy extract than in the uncoated magnesium alloy extract. In summary, the results indicate that the Ca-P coating can improve the corrosion resistance of magnesium alloy and elevate cellular proliferation and differentiation of osteoblast MC3T3-E1 cells.</abstract><cop>Heidelberg</cop><pub>Jilin University and The Editorial Department of Chemical Research in Chinese Universities</pub><doi>10.1007/s40242-013-2314-5</doi><tpages>5</tpages></addata></record> |
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| subjects | Analytical Chemistry Chemistry Chemistry and Materials Science Chemistry/Food Science Inorganic Chemistry Mg-Al合金 Organic Chemistry Physical Chemistry 体外降解 八肽胆囊收缩素 涂层制备 生物相容性 碱性磷酸酶活性 钙化合物 镁合金 |
| title | In vitro Degradation and Biocompatibility of Ca-P Coated Magnesium Alloy |
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