In vitro Degradation and Biocompatibility of Ca-P Coated Magnesium Alloy

Calcium-phosphate compounds(Ca-P) coating was prepared on an Mg-A1 alloy(AZ60). Biodegradation of Ca-P coated magnesium alloy was evaluated in simulated body fluid(SBF) by examining the changes in magnesium ion concentration and pH value, which indicated that the Ca-P coating on magnesium alloy stro...

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Veröffentlicht in:Chemical research in Chinese universities 2013-04, Vol.29 (2), p.285-289
Hauptverfasser: Xiao, Xing, Zhu, Qing-san, Su, Ying-chao, Li, Guang-yu
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Sprache:eng
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Zusammenfassung:Calcium-phosphate compounds(Ca-P) coating was prepared on an Mg-A1 alloy(AZ60). Biodegradation of Ca-P coated magnesium alloy was evaluated in simulated body fluid(SBF) by examining the changes in magnesium ion concentration and pH value, which indicated that the Ca-P coating on magnesium alloy strongly affected the cor- rosion of magnesium alloy. Osteoblast MC3T3-E1 cells were utilized to investigate the cellular eytocompatibility. The cytocompatibility was measured by carrying out a series of tests, such as cholecystokinin-octapeptide(CCK-8) test, alkaline phosphatase activity(ALP) test, cellular morphology of hematoxylin-eosin(HE) staining and the induc- tion of apoptosis. It was found that the cell function showed better in the Ca-P coated Mg-alloy extract than in the uncoated magnesium alloy extract. In summary, the results indicate that the Ca-P coating can improve the corrosion resistance of magnesium alloy and elevate cellular proliferation and differentiation of osteoblast MC3T3-E1 cells.
ISSN:1005-9040
2210-3171
DOI:10.1007/s40242-013-2314-5