Kinetic Studies on Aniline-catalyzed Carbohydrate Oxime Formation via Real-time NMR

Kinetic Studies on Aniline-catalyzed Carbohydrate Oxime Formation via Real-time NMR

The authors investigated an aniline-catalyzed method to accelerate the reaction between equimolar reducing glycans and hydroxylamines. The rate-constants determined by real-time NMR were associated with the equivalence ratio of aniline rather than the concentration. Conjugates of oligosaccharide wit...

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Veröffentlicht in:高等学校化学研究（英文版） 2011-09, Vol.27 (5), p.886-890
1. Verfasser: WANG Wen-jun CAO Chen-ming JIN Chen WANG Xin WANG George-peng
Format: Artikel
Sprache:eng
Schlagworte:
偶联效率
催化方法
动力学
实时
核磁共振
碳水化合物
苯胺
速率常数
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Zusammenfassung:The authors investigated an aniline-catalyzed method to accelerate the reaction between equimolar reducing glycans and hydroxylamines. The rate-constants determined by real-time NMR were associated with the equivalence ratio of aniline rather than the concentration. Conjugates of oligosaccharide with hydroxylamine can be obtained in high efficiency at pH=5.4.
ISSN:1005-9040
2210-3171