Comparison of BSA Release Behavior from Electrospun PLGA and PLGA/Chitosan Membranes
In order to encapsulate and controlled-release bioactive proteins,three fibrous membranes,i.e.,poly（L-lactide-co-glycolide）（PLGA）,hybrid PLGA and chitosan（H-PLGA/CS）,and core/shell PLGA/CS （C-PLGA/CS）,were produced by emulsion electrospinning,co-electrospinning and coaxial electrospinning,respective...
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| Veröffentlicht in: | 高等学校化学研究（英文版） 2011-07, Vol.27 (4), p.708-711 |
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| container_title | 高等学校化学研究（英文版） |
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| creator | WU Li-li LI Xiao-ran LI Hua YUAN Xiao-yan |
| description | In order to encapsulate and controlled-release bioactive proteins,three fibrous membranes,i.e.,poly（L-lactide-co-glycolide）（PLGA）,hybrid PLGA and chitosan（H-PLGA/CS）,and core/shell PLGA/CS （C-PLGA/CS）,were produced by emulsion electrospinning,co-electrospinning and coaxial electrospinning,respectively.Bovine serum albumin（BSA） was selected as a model protein.The loading efficiency of BSA in the PLGA membrane was 1.56%,lower than those of H-PLGA/CS（5.98%） and C-PLGA/CS（4.80%）.BSA release profiles from the three membranes showed initial burst releases in the first 7 d and then sustained release for 28 d.Cumulative releases at the end of the releasing period,28 d,from the above three membranes were nearly 63%,88% and 94%,respectively,indicating that the introduction of chitosan and the core/shell fiber structure could enhance BSA release rate.In addition,all these electrospun membranes could retain their fibrous morphologies after in vitro release of BSA for 28 d. |
| format | Article |
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Ltd. All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/86071X/86071X.jpg</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>WU Li-li LI Xiao-ran LI Hua YUAN Xiao-yan</creatorcontrib><title>Comparison of BSA Release Behavior from Electrospun PLGA and PLGA/Chitosan Membranes</title><title>高等学校化学研究（英文版）</title><addtitle>Chemical Research in Chinese University</addtitle><description>In order to encapsulate and controlled-release bioactive proteins,three fibrous membranes,i.e.,poly（L-lactide-co-glycolide）（PLGA）,hybrid PLGA and chitosan（H-PLGA/CS）,and core/shell PLGA/CS （C-PLGA/CS）,were produced by emulsion electrospinning,co-electrospinning and coaxial electrospinning,respectively.Bovine serum albumin（BSA） was selected as a model protein.The loading efficiency of BSA in the PLGA membrane was 1.56%,lower than those of H-PLGA/CS（5.98%） and C-PLGA/CS（4.80%）.BSA release profiles from the three membranes showed initial burst releases in the first 7 d and then sustained release for 28 d.Cumulative releases at the end of the releasing period,28 d,from the above three membranes were nearly 63%,88% and 94%,respectively,indicating that the introduction of chitosan and the core/shell fiber structure could enhance BSA release rate.In addition,all these electrospun membranes could retain their fibrous morphologies after in vitro release of BSA for 28 d.</description><subject>BSA</subject><subject>PLGA</subject><subject>壳聚糖膜</subject><subject>曲线显示</subject><subject>牛血清白蛋白</subject><subject>生物活性</subject><subject>释放行为</subject><subject>静电纺丝</subject><issn>1005-9040</issn><issn>2210-3171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNotkE9PAjEUxBujiYh-h3r0sPG1-7dH2CCYYDSK583b7iu7hG2xBYVv70Y8zRx-mcnMBRtJKSCKRS4u2UgApJGCBK7ZTQgbgFhlWTJiq9L1O_RdcJY7w6cfE_5OW8JAfEotfnfOc-Ndz2db0nvvwu5g-dtyPuFomz_zWLbd3gW0_IX62qOlcMuuDG4D3f3rmH0-zVblIlq-zp_LyTLSUqT7KE7zzOR1AaQwKbTRWiYNFYVBBQDKkFAo60wSQdEoBKNMgrUQda51TjnEY_Zwzv1Ba9Cuq407eDs0VuvmeGyPp40EIYbRsRrY-zOrW2fXX91A73zXoz9V8fBLJgfqF3uWWlU</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>WU Li-li LI Xiao-ran LI Hua YUAN Xiao-yan</creator><general>Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering,Tianjin University, Tianjin 300072, P.R.China</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>~WA</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope></search><sort><creationdate>20110701</creationdate><title>Comparison of BSA Release Behavior from Electrospun PLGA and PLGA/Chitosan Membranes</title><author>WU Li-li LI Xiao-ran LI Hua YUAN Xiao-yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c215t-3576f7b80e9a48cfcc24de88fa90009fe19a2b62ee08d9a0f9f4ab11b7cc7e703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>BSA</topic><topic>PLGA</topic><topic>壳聚糖膜</topic><topic>曲线显示</topic><topic>牛血清白蛋白</topic><topic>生物活性</topic><topic>释放行为</topic><topic>静电纺丝</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WU Li-li LI Xiao-ran LI Hua YUAN Xiao-yan</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><jtitle>高等学校化学研究（英文版）</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WU Li-li LI Xiao-ran LI Hua YUAN Xiao-yan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of BSA Release Behavior from Electrospun PLGA and PLGA/Chitosan Membranes</atitle><jtitle>高等学校化学研究（英文版）</jtitle><addtitle>Chemical Research in Chinese University</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>27</volume><issue>4</issue><spage>708</spage><epage>711</epage><pages>708-711</pages><issn>1005-9040</issn><eissn>2210-3171</eissn><abstract>In order to encapsulate and controlled-release bioactive proteins,three fibrous membranes,i.e.,poly（L-lactide-co-glycolide）（PLGA）,hybrid PLGA and chitosan（H-PLGA/CS）,and core/shell PLGA/CS （C-PLGA/CS）,were produced by emulsion electrospinning,co-electrospinning and coaxial electrospinning,respectively.Bovine serum albumin（BSA） was selected as a model protein.The loading efficiency of BSA in the PLGA membrane was 1.56%,lower than those of H-PLGA/CS（5.98%） and C-PLGA/CS（4.80%）.BSA release profiles from the three membranes showed initial burst releases in the first 7 d and then sustained release for 28 d.Cumulative releases at the end of the releasing period,28 d,from the above three membranes were nearly 63%,88% and 94%,respectively,indicating that the introduction of chitosan and the core/shell fiber structure could enhance BSA release rate.In addition,all these electrospun membranes could retain their fibrous morphologies after in vitro release of BSA for 28 d.</abstract><pub>Tianjin Key Laboratory of Composite and Functional Materials, School of Materials Science and Engineering,Tianjin University, Tianjin 300072, P.R.China</pub><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 1005-9040 |
| ispartof | 高等学校化学研究（英文版）, 2011-07, Vol.27 (4), p.708-711 |
| issn | 1005-9040 2210-3171 |
| language | eng |
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| source | Alma/SFX Local Collection |
| subjects | BSA PLGA 壳聚糖膜 曲线显示 牛血清白蛋白 生物活性 释放行为 静电纺丝 |
| title | Comparison of BSA Release Behavior from Electrospun PLGA and PLGA/Chitosan Membranes |
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