Comparison of BSA Release Behavior from Electrospun PLGA and PLGA/Chitosan Membranes

In order to encapsulate and controlled-release bioactive proteins,three fibrous membranes,i.e.,poly(L-lactide-co-glycolide)(PLGA),hybrid PLGA and chitosan(H-PLGA/CS),and core/shell PLGA/CS (C-PLGA/CS),were produced by emulsion electrospinning,co-electrospinning and coaxial electrospinning,respective...

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Veröffentlicht in:高等学校化学研究(英文版) 2011-07, Vol.27 (4), p.708-711
1. Verfasser: WU Li-li LI Xiao-ran LI Hua YUAN Xiao-yan
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Sprache:eng
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Zusammenfassung:In order to encapsulate and controlled-release bioactive proteins,three fibrous membranes,i.e.,poly(L-lactide-co-glycolide)(PLGA),hybrid PLGA and chitosan(H-PLGA/CS),and core/shell PLGA/CS (C-PLGA/CS),were produced by emulsion electrospinning,co-electrospinning and coaxial electrospinning,respectively.Bovine serum albumin(BSA) was selected as a model protein.The loading efficiency of BSA in the PLGA membrane was 1.56%,lower than those of H-PLGA/CS(5.98%) and C-PLGA/CS(4.80%).BSA release profiles from the three membranes showed initial burst releases in the first 7 d and then sustained release for 28 d.Cumulative releases at the end of the releasing period,28 d,from the above three membranes were nearly 63%,88% and 94%,respectively,indicating that the introduction of chitosan and the core/shell fiber structure could enhance BSA release rate.In addition,all these electrospun membranes could retain their fibrous morphologies after in vitro release of BSA for 28 d.
ISSN:1005-9040
2210-3171