Practical and Efficient Acylation and Tosylation of Sterically Hindered Alcohols Catalyzed with 1-Methylimidazole
Acylation of sterically hindered alcohols is frequently encountered in synthetic chemistry. An efficient and mild procedure for tosylation and esterification of sterically hindered hydroxyl groups with p-TsCl, Ac20 and Bz20 in the presence of l-methylimidazole is described. It was observed that auxi...
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| Veröffentlicht in: | Chemical research in Chinese universities 2010, Vol.26 (1), p.55-59 |
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| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | Acylation of sterically hindered alcohols is frequently encountered in synthetic chemistry. An efficient and mild procedure for tosylation and esterification of sterically hindered hydroxyl groups with p-TsCl, Ac20 and Bz20 in the presence of l-methylimidazole is described. It was observed that auxiliary base, triethylamine, accelerates the acylation reaction. |
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| ISSN: | 1005-9040 2210-3171 |