Synthesis, Characterization and Cytotoxicity of Ammine/Methylamine Platinum (II) Complexes with Carboxylates

Seven novel platinum (II) complexes [Pt (II) (NH 3) (CH 3NH 2) X 2] (I—VII) (X: CH 3COO −, CH 2ClCOO −, CHCl 2COO −, C 6H 5 COO −, p-CH 3 O C 6 H 4 COO −, p-NH 2 C 6H 4 COO −, p-NO 2 C 6H 4 COO −) were prepared and characterized by means of elemental analysis, molar conductivity, thermal analysis, IR, UV, and 1H NMR spectrometries. The cytotoxicity against HCT-8, BGC-823, MCF-7, EJ, and HL-60 cell lines increases in the following sequence: cisplatin > IV > V > VI > VII > I > II > III. Moreover, the complexes (I — VII) display substantially greater activities against EJ and HL-60 cell lines than those against the cell lines from other carcinomas. They can induce a concentration-dependent accumulation of HL-60 cells in the G 2/M phase of the cell cycle as cisplatin. There is no significant correlation between total DNA platination levels and cytotoxicity of the complexes.