Polarographic Studies on Associations of Midecamycin and Chloroquine with Hydrogen Peroxide

The associations of each of midecamycin and chloroquine phosphate to hydrogen peroxide were studied by using linear-potential scan polarography. In a 0. 15mol/L KH2PO4-NaOH (pH 7.4) buffer, the association ratio of the association complex of midecamycin to hydrogen peroxide is 1:1, and the apparent association constant is 7.18. While in a 0. 04 mol/L NH3· H2O-NH4Cl(pH9. 5) buffer, the association ratio and the apparent association constant of the association complex of chloroquine phosphate to hydrogen peroxide are 1:1 and 45.4, respectively. The formation of the association complexes stabilizes H2O2 and results in the accumulation of H2O2, which is baneful to human body.