Halodemetallation of (Z)-1-[2-(Triarylstannyl)vinyl]-cyclooctanol and Correlation of Proton Chemical Shift with Electronegativity

Introduction Organotin compounds have attracted attention as an optimal model for antitumour agents due to the function of the interesting intramolecular O→Sn coordination[1,2]. Our recent concern has been focused on the preparation of (Z)-1-[2-(triarylstannyl)vinyl]-cyclooctanol[3]. In order to find more appropriate compounds used as anticancer agents and explore the effect of the coordinate O→Sn interaction to the antitumor activity, the new compounds were halodemetallated and characterized. During the course of the process, some linear correlations between proton chemical shifts and the sum of the electronegativities of the tin substituents of halogens were found for the first time. ……