Improved Fibroblast Adhesion and Proliferation by Controlling Multi-level Structure of Polycaprolactone Microfiber

R318.08%TQ340.64; Improving wound healing efficiency is a key issue for high performance dressings. The surface topology of fibers in wound dressings plays an important role in regulating cell behaviors during the regeneration. Herein, a polycaprolactone ( PCL ) scaffold with a shish-kebab structure was prepared by electrospinning and solution-induced crystallization. L929 cells were used to investigate the behavior of fibroblasts on the multi-level microfiber. The results showed that the shish-kebab fiber-based scaffold enhanced the cell proliferation when compared with the normal fiber and the fiber with a porous structure. Protein absorption, cell adhesive force, and cell modulus also increased by the shish-kebab fiber. The shish-kebab fiber-based scaffold with improved fibroblast-regulation ability can be applied in rapid wound healing.