Collagen/Chitosan Electrospun Nanofibrous Membrane for Wound Dressing

Collagen （Col）/chitasan （CS） nanofibrous membrane has great potential to be used as wound dressing. However, current Coi/CS nanofibrous membrane produced from elertrospinning call not offer sufficient mechanical strength for practical applications. Herein, a novel mixed solvent was used to prepare next-generation hlgh-strength Col/CS nanofibrous membrane. Meanwhile, the optimal Col to CS weight ratio was investigated as well. The asproduced membrane was examined by scanning electron microscopy （SEM）, attenuated total reflectance Fourier transform infrared spectroscopy （ATR-FFIR）, differential SCanning calorimetry （DSC）, and XF-1A tester to study its morpliological, chemical, thermal and mechanical properties. The preliminary results demonstrated that the mechanical properties of Col/CS nanofibrous membranes were enhanced substantially with the increase of CS weight ratios from 0 to 90% and the optimal Col to CS weight ratio was determined to be 1 ： 1. A promising way was presented to fabricate Col/CS dectrospun nanofibrous membrane with sufficient mechanical strength for practical wound dressing applications.