Advances in pharmacotherapies in cancer-related cachexia

Cancer-related cachexia is highly prevalent in patients with advanced cancer,affecting approximately 50%-80%of patients and seriously interfering with active therapy,quality of life,and survival time.There are currently no effective treatments for cachexia.Therefore,new therapeutic strategies are required.In recent years,advances in understanding the mechanisms underlying cachexia have been made,and new drugs have been developed to combat cachexia muscle wasting and weight loss due to cancer.In this systematic review,we discuss these novel targets and drug treatments.