Genetic Basis of Gastric Cancer

Gastric cancer is the result of multiple risk factors, including environmental factors, genetic factors and the interaction between them. The environmental factors mainly include dietary, Helicobacter pylori infection and family history of gastric cancer. Genetic factors mainly refer to the suscepti...

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Veröffentlicht in:	Chinese medical sciences journal 2016-09, Vol.31 (3), p.192-195
Hauptverfasser:	Gao, Yue-wen, Zhang, Chun-hua, Zuo, Xing-mei, Hui, Xi-zeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Cyclin-Dependent Kinase Inhibitor p15 - genetics DNA修复基因 gastric cancer Genes, p16 Genes, Tumor Suppressor genetic factors Humans Oncogenes Stomach Neoplasms - etiology Stomach Neoplasms - genetics 幽门螺杆菌抑癌基因易感基因环境因素胃癌遗传因素遗传基础
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Beschreibung
Zusammenfassung:	Gastric cancer is the result of multiple risk factors, including environmental factors, genetic factors and the interaction between them. The environmental factors mainly include dietary, Helicobacter pylori infection and family history of gastric cancer. Genetic factors mainly refer to the susceptible genes that cause epigenetic alterations in oncogenes, tumor suppress genes, cell cycle regulators, DNA repair genes and signaling molecules. This paper summarizes the susceptible genes of gastric cancer and explores the genetic basis of it.
ISSN:	1001-9294
DOI:	10.1016/S1001-9294(16)30050-5