Aberrant Expression of Kiss-1 and Matrix Metalloproteinase-9 Are Closely Linked to Lymph Node Metastasis of Gastric Cancer

China is one of the countries with the highest risk of gastric cancer over the past century, which is still the leading cause of death worldwide. Because metastatic disease of gastric cancer is the most critical impediment to patient survival, it is necessary to further understand the molecular mechanisms of its metastasis. Kiss-1, mapping to chromosome 1q32, is one of these genes regulated at chromosome 6. Kiss-1 expression was discovered to inhibit metastasis in both in vivo melanoma and breast carcinoma models. Mounting clinical evidences, particularly the loss of Kiss-1 in metastases, correlates Kiss-1 and metastin receptor expression with human tumor progression.