STUDY OF THE RELATIONSHIP BETWEEN PSORIASIS AND THE POLYMORPHIC SITE C677T OF METHYLENETETRAHYDROFOLATE REDUCTASE

STUDY OF THE RELATIONSHIP BETWEEN PSORIASIS AND THE POLYMORPHIC SITE C677T OF METHYLENETETRAHYDROFOLATE REDUCTASE

Objective. In order to investigate 5, l0-methylenetetrahydrofolate reductase (MTHFR)'s polymorphic changes in psoriasis vulgaris. Methods. We detected mutation of site C677V of MTHFR in 39 psoriasfics by PCR-RFLP. Results. Genotype frequencies of the psoriasfics were C/C= 20.15%,C/T= 48.72% and...

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Veröffentlicht in:Chinese medical sciences journal 2000-06, Vol.15 (2), p.119-120
1. Verfasser: 王柏秋 傅松滨 张贵寅 李严璞
Format: Artikel
Sprache:eng
Schlagworte:
C677T
Gene Frequency
Humans
Methylenetetrahydrofolate Reductase (NADPH2) - genetics
MTHFR
PCR-RFLP
Point Mutation
Polymorphism, Restriction Fragment Length
Psoriasis - enzymology
Psoriasis - genetics
牛皮癣
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Zusammenfassung:Objective. In order to investigate 5, l0-methylenetetrahydrofolate reductase (MTHFR)'s polymorphic changes in psoriasis vulgaris. Methods. We detected mutation of site C677V of MTHFR in 39 psoriasfics by PCR-RFLP. Results. Genotype frequencies of the psoriasfics were C/C= 20.15%,C/T= 48.72% and T/T= 30.77%; the allelic frequencies were C = 0.4487 and T=0.5513. Homozygous mutant (TT) of the psoriastics was significantly different from the normal control goup by X2 test. Conclusion. C677V mutant of MTHFR might be related with psoriasis.
ISSN:1001-9294