THE TRANSMEMBRANE SIGNAL TRANSDUCTION IN HEp-2 CELLS INDUCED BY BACTERIAL ADHERENCE

In order to understand the role of transmembrane signal transduction of host cells in the early steps of infection,the adherence of E. coli to HEp-2 cells and the change of activity of phospholipase C-γ (PLC-γ) induced by the adherence were investigated. The adherence of enteropathogenic E. coli (EP...

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Veröffentlicht in:	Chinese medical sciences journal 2000-03, Vol.15 (1), p.20-23
1. Verfasser:	管远志薛莉叶菜英张德昌
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Adhesion Escherichia coli - physiology Fimbriae, Bacterial - physiology HEp-2细胞 Inositol Phosphates - metabolism Laryngeal Neoplasms Phospholipase C gamma Signal Transduction Tumor Cells, Cultured Type C Phospholipases - metabolism 信号转换横跨膜细胞粘附细菌感染
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Zusammenfassung:	In order to understand the role of transmembrane signal transduction of host cells in the early steps of infection,the adherence of E. coli to HEp-2 cells and the change of activity of phospholipase C-γ (PLC-γ) induced by the adherence were investigated. The adherence of enteropathogenic E. coli (EPEC), strain E. 7, induced a significant increase of inositol-triphosphat (IP-3) level in HEp-2 cells. The adherence of the bacteria and the increase of IP-3 was kinetically correlated.Whereas the increase of IP3 level induced by the adherence of the control strain EPEC (H511), a non-piliated strain, was much meager than that by E7, a piliated strain. The results highlighted an important role of transmernbrane signals like IP-3 in the pathogenesis of EPEC.
ISSN:	1001-9294