Effect of Perinatal Bisphenol A Exposure on Serum Lipids and Lipid Enzymes in Offspring Rats of Different Sex

Rats were exposed to 1 or 10 µg/mL bisphenol A (BPA) in water during pregnancy and lactation. Offspring rats were given normal water and a standard diet from weaning to postnatal day (PND) 50. Perinatal exposure to BPA resulted in significantly increased body weight, visceral adipose tissue, abnorma...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biomedical and environmental sciences 2016-09, Vol.29 (9), p.686-689
Hauptverfasser:	GAO, Liang, WANG, Han Ning, ZHANG, Ling, PENG, Fang Yuan, JIA, Yue, WEI, Wei, JIA, Li Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiponectin - metabolism Adipose Tissue - metabolism Animals Benzhydryl Compounds - adverse effects Benzhydryl Compounds - metabolism Body Weight Dyslipidemias - enzymology Dyslipidemias - etiology Dyslipidemias - metabolism Dyslipidemias - physiopathology Female Humans Lipase - genetics Lipase - metabolism Lipids - blood Male Obesity - enzymology Obesity - etiology Obesity - metabolism Obesity - physiopathology Phenols - adverse effects Phenols - metabolism Pregnancy Prenatal Exposure Delayed Effects - enzymology Prenatal Exposure Delayed Effects - etiology Prenatal Exposure Delayed Effects - metabolism Prenatal Exposure Delayed Effects - physiopathology Rats Rats, Sprague-Dawley
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Rats were exposed to 1 or 10 µg/mL bisphenol A (BPA) in water during pregnancy and lactation. Offspring rats were given normal water and a standard diet from weaning to postnatal day (PND) 50. Perinatal exposure to BPA resulted in significantly increased body weight, visceral adipose tissue, abnormal serum lipids, and lower adiponectin (ADP) levels in both female and male offspring rats. Liver adipose triglyceride lipase (Atgl) mRNA levels and ADP protein in visceral adipose tissue were significantly decreased in BPA-exposed offspring rats. In both female or male offspring rats, obesity and dyslipidemia induced by perinatal exposure to BPA were associated with down regulation of Atgl mRNA in liver and ADP protein in visceral adipose tissue.
ISSN:	0895-3988 2214-0190
DOI:	10.3967/bes2016.092