Expression of Peroxiredoxins and Pulmonary Surfactant Protein A Induced by Silica in Rat Lung Tissue

Silicosis is one of the most serious occupational diseases in China and dates back to centuries ago. In this study, we successfully established a rat model of silicosis by intratracheal silica injection for 28 days and determined hydroxyproline levels to evaluate collagen metabolism in lung homogena...

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Veröffentlicht in:	Biomedical and environmental sciences 2016-08, Vol.29 (8), p.584-588
Hauptverfasser:	LIU, Nan, XUE, Ling, GUAN, Yi, LI, Qing Zhao, CAO, Fu Yuan, PANG, Shu Lan, GUAN, Wei Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Humans Lung - enzymology Lung - metabolism Male Oxidative Stress Peroxiredoxin VI - genetics Peroxiredoxin VI - metabolism Peroxiredoxins - genetics Peroxiredoxins - metabolism Pulmonary Surfactant-Associated Protein A - genetics Pulmonary Surfactant-Associated Protein A - metabolism Rat Rats Silicon Dioxide - toxicity Silicosis - genetics Silicosis - metabolism 二氧化硅活性蛋白石英矽肺表面谷胱甘肽过氧化物酶活性过氧化氢酶
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Zusammenfassung:	Silicosis is one of the most serious occupational diseases in China and dates back to centuries ago. In this study, we successfully established a rat model of silicosis by intratracheal silica injection for 28 days and determined hydroxyproline levels to evaluate collagen metabolism in lung homogenates. Oxidative stress status was evaluated by detecting catalase and glutathione peroxidase activities.
ISSN:	0895-3988 2214-0190
DOI:	10.3967/bes2016.077