Exploring Genome-wide DNA Methylation Profiles Altered in Kashin-Beck Disease Using Infinium Human Methylation 450 Bead Chips

To understand how differentially methylated genes（DMGs）might affect the pathogenesis of Kashin-Beck disease（KBD）.Genome-wide methylation profiling of whole blood from 12matched KBD and controls pairs was performed using a high-resolution Infinium 450 K methylation array.In total,97 CpG sites were di...

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Veröffentlicht in:	Biomedical and environmental sciences 2016-07, Vol.29 (7), p.539-543
Hauptverfasser:	SHI, Xiao Wei, SHI, Bo Hui, LYU, Ai Li, ZHANG, Feng, ZHOU, Tian Tian, GUO, Xiong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Case-Control Studies Cluster Analysis CpG Islands DNA Methylation Female Genetic Variation Genome-Wide Association Study Humans Kashin-Beck Disease - genetics Middle Aged Oligonucleotide Array Sequence Analysis
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Zusammenfassung:	To understand how differentially methylated genes（DMGs）might affect the pathogenesis of Kashin-Beck disease（KBD）.Genome-wide methylation profiling of whole blood from 12matched KBD and controls pairs was performed using a high-resolution Infinium 450 K methylation array.In total,97 CpG sites were differentially
ISSN:	0895-3988 2214-0190
DOI:	10.3967/bes2016.072