Role of Fas/FasL Pathway-mediated Alveolar Macrophages Releasing Inflammatory Cytokines in Human Silicosis

The role of Fas/Fas ligand （FasL） in mediating alveolar macrophage （AM）-derived inflammatory cytokines in 29 human lung silicosis patients and 6 controls was studied. It showed that the serum levels of IL-1β, TNF-a, IL-8, MIP-la, MCP-1, and TGF-β1 were higher in silicosis patients than in controls,...

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Veröffentlicht in:	Biomedical and environmental sciences 2013-11, Vol.26 (11), p.930-933
Hauptverfasser:	YAO, San Qiao, HE, Qin Cheng, YUAN, Ju Xiang, CHEN, Jie, CHEN, Gang, LU, Yao, BAI, Yu Ping, ZHANG, Chun Min, YUAN, Yang, XU, Ying Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Monoclonal - pharmacology Bronchoalveolar Lavage Fluid - cytology Cells, Cultured Cytokines - biosynthesis Cytokines - blood Cytokines - secretion Fas Ligand Protein - antagonists & inhibitors Fas Ligand Protein - metabolism fas Receptor - antagonists & inhibitors fas Receptor - metabolism FasL Humans Macrophages, Alveolar - immunology Macrophages, Alveolar - metabolism MCP-1 Middle Aged Occupational Exposure - analysis Signal Transduction Silicon Dioxide - adverse effects Silicosis - blood Silicosis - immunology TGF-β 介导炎症矽肺细胞因子肺泡巨噬细胞
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Zusammenfassung:	The role of Fas/Fas ligand （FasL） in mediating alveolar macrophage （AM）-derived inflammatory cytokines in 29 human lung silicosis patients and 6 controls was studied. It showed that the serum levels of IL-1β, TNF-a, IL-8, MIP-la, MCP-1, and TGF-β1 were higher in silicosis patients than in controls, and increased with the progression of silicosis except TGF-β1 and IL-8. TGF-β1, IL-8, MCP-1,
ISSN:	0895-3988 2214-0190
DOI:	10.3967/bes2013.024