The Mechanism of Acute Lung Injury Induced by Nickel Carbonyl in Rats

Nickel carbonyl is a highly toxic metal compound produced from the reaction that occurs between nickel and carbon monoxide under pressure. As previously reported, nickel carbonyl can cause acute aspiration pneumonia, and animal experiments showed it was toxic to animal lung, liver, brain, and other...

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Veröffentlicht in:	Biomedical and environmental sciences 2013-07, Vol.26 (7), p.625-628
Hauptverfasser:	BAI, Ya Na, MA, Li, WANG, Qiu Ying, PU, Hong Quan, ZHANG, Xiao Pei, WU, Xi Jiang, XUAN, Xiao Qiang, CHENG, Ning
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - chemically induced Acute Lung Injury - metabolism Acute Lung Injury - pathology Animals CDC2 Protein Kinase - genetics CDC2 Protein Kinase - metabolism Cell Cycle - drug effects Checkpoint Kinase 1 Female Lung - metabolism Lung - pathology Lung - ultrastructure Male Malondialdehyde - metabolism Microscopy, Electron, Transmission Organometallic Compounds - toxicity Oxidative Stress Protein Kinases - genetics Protein Kinases - metabolism Rats Rats, Sprague-Dawley RNA, Messenger - metabolism 一氧化碳动物实验大鼠急性损伤机制羰基镍肺炎金属化合物
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Beschreibung
Zusammenfassung:	Nickel carbonyl is a highly toxic metal compound produced from the reaction that occurs between nickel and carbon monoxide under pressure. As previously reported, nickel carbonyl can cause acute aspiration pneumonia, and animal experiments showed it was toxic to animal lung, liver, brain, and other vital organs[1]. However, few studies have investigated nickel carbonyl poisoning in humans.
ISSN:	0895-3988 2214-0190
DOI:	10.3967/0895-3988.2013.07.018