Anti-inflammatory nutrition with high protein attenuates cardiac and skeletal muscle alterations in a pulmonary arterial hypertension model

Pulmonary arterial hypertension (PAH) is characterized by remodelling of the pulmonary arteries and right ventricle (RV), which leads to functional decline of cardiac and skeletal muscle. This study investigated the effects of a multi-targeted nutritional intervention with extra protein, leucine, fi...

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Veröffentlicht in:	Scientific reports 2019-07, Vol.9 (1), p.10160-11, Article 10160
Hauptverfasser:	Vinke, Paulien, Bowen, T. Scott, Boekschoten, Mark. V., Witkamp, Renger F., Adams, Volker, van Norren, Klaske
Format:	Artikel
Sprache:	eng
Schlagworte:	13 38 38/61 64/60 692/4019/592/1540 692/4019/592/2725 692/699/75 82/80 Animals Atrophy Cardiomegaly - diet therapy Cardiomegaly - physiopathology Chair Nutrition and Pharmacology (HNE) Chair Nutrition Metabolism and Genomics Chair Sensory Science and Eating Behaviour Disease Models, Animal Female Fibrosis Fibrosis - metabolism Fish oils Heart - physiopathology Heart Ventricles - physiopathology HNE Nutrition and Pharmacology HNE Nutrition, Metabolism and Genomics HNE Sensoriek en Eetgedrag HNE Sensory Science and Eating Behaviour HNE Voeding en Farmacologie HNE Voeding, Metabolisme en Genomics Humanities and Social Sciences Hypertension Hypertension, Pulmonary - physiopathology Hypertrophy, Right Ventricular - diet therapy Inflammation Leucine Mice Mice, Inbred C57BL Monocrotaline Monocrotaline - pharmacology multidisciplinary Muscle, Skeletal - metabolism Musculoskeletal system Nutrition, Metabolism and Genomics Nutritional Biology and Health Oligosaccharides Pulmonary Arterial Hypertension - diet therapy Pulmonary Arterial Hypertension - metabolism Pulmonary arteries Pulmonary artery Pulmonary Artery - pathology Pulmonary hypertension Science Science (multidisciplinary) Sensoriek en eetgedrag Sensory Science and Eating Behaviour Skeletal muscle Vascular Remodeling - drug effects Ventricle Ventricular Function, Right VLAG Voeding, Metabolisme en Genomica Voedingsbiologie en Gezondheid
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Zusammenfassung:	Pulmonary arterial hypertension (PAH) is characterized by remodelling of the pulmonary arteries and right ventricle (RV), which leads to functional decline of cardiac and skeletal muscle. This study investigated the effects of a multi-targeted nutritional intervention with extra protein, leucine, fish oil and oligosaccharides on cardiac and skeletal muscle in PAH. PAH was induced in female C57BL/6 mice by weekly injections of monocrotaline (MCT) for 8 weeks. Control diet (sham and MCT group) and isocaloric nutritional intervention (MCT + NI) were administered. Compared to sham, MCT mice increased heart weight by 7%, RV thickness by 13% and fibrosis by 60% (all p
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-019-46331-4