Exopolysaccharides synthesized by Bifidobacterium animalis subsp. lactis interact with TLR4 in intestinal epithelial cells

Exopolysaccharides synthesized by Bifidobacterium animalis subsp. lactis interact with TLR4 in intestinal epithelial cells

The toll-like receptors involved in recognition of the exopolysaccharide produced by two isogenic, ropy and non-ropy, Bifidobacterium animalis subsp. lactis strains were investigated. Both strains interact with human embryonic kidney (HEK)-293 cells via TLR2, whereas purified EPSs specifically stimu...

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Veröffentlicht in:Anaerobe 2019-04, Vol.56, p.98-101
Hauptverfasser: Castro-Bravo, Nuria, Margolles, Abelardo, Wells, Jerry M., Ruas-Madiedo, Patricia
Format: Artikel
Sprache:eng
Schlagworte:
Host Microbe Interactomics
Leerstoelgroep Host Microbe Interactomics
VLAG
WIAS
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Zusammenfassung:The toll-like receptors involved in recognition of the exopolysaccharide produced by two isogenic, ropy and non-ropy, Bifidobacterium animalis subsp. lactis strains were investigated. Both strains interact with human embryonic kidney (HEK)-293 cells via TLR2, whereas purified EPSs specifically stimulate TLR4 regardless their molar mass. [Display omitted] •Bifidobacterium animalis subsp. lactis strains interact with TRL2.•EPS purified from bifidobacteria trigger a response of TLR4.•The molar mass of EPS doesn't account for TLR4 interaction.
ISSN:1075-9964
1095-8274
DOI:10.1016/j.anaerobe.2019.02.014