Genome-wide association meta-analysis of coronary artery disease and periodontitis reveals a novel shared risk locus

Genome-wide association meta-analysis of coronary artery disease and periodontitis reveals a novel shared risk locus

Evidence for a shared genetic basis of association between coronary artery disease (CAD) and periodontitis (PD) exists. To explore the joint genetic basis, we performed a GWAS meta-analysis. In the discovery stage, we used a German aggressive periodontitis sample (AgP-Ger; 680 cases vs 3,973 control...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Scientific reports 2018-09, Vol.8 (1), p.13678-10, Article 13678
Hauptverfasser: Munz, Matthias, Richter, Gesa M., Loos, Bruno G., Jepsen, Søren, Divaris, Kimon, Offenbacher, Steven, Teumer, Alexander, Holtfreter, Birte, Kocher, Thomas, Bruckmann, Corinna, Jockel-Schneider, Yvonne, Graetz, Christian, Munoz, Loreto, Bhandari, Anita, Tennstedt, Stephanie, Staufenbiel, Ingmar, van der Velde, Nathalie, Uitterlinden, André G., de Groot, Lisette C. P. G. M., Wellmann, Jürgen, Berger, Klaus, Krone, Bastian, Hoffmann, Per, Laudes, Matthias, Lieb, Wolfgang, Franke, Andre, Dommisch, Henrik, Erdmann, Jeanette, Schaefer, Arne S.
Format: Artikel
Sprache:eng
Schlagworte:
45/43
631/208/205/2138
692/420/256/2515
Cardiovascular disease
Chair Nutrition and Health over the Lifecourse
Coronary artery
Coronary vessels
Environmental risk
Genomes
Global Nutrition
Gum disease
Haplotypes
Heart diseases
HNE Nutrition and Health over the Lifecourse
HNE Voeding en Gezondheid in de Levenscyclus
Humanities and Social Sciences
Immune system
Membrane trafficking
Meta-analysis
multidisciplinary
Periodontitis
Replication
Risk factors
Risk sharing
Science
Science (multidisciplinary)
Single-nucleotide polymorphism
VLAG
Wereldvoeding
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Evidence for a shared genetic basis of association between coronary artery disease (CAD) and periodontitis (PD) exists. To explore the joint genetic basis, we performed a GWAS meta-analysis. In the discovery stage, we used a German aggressive periodontitis sample (AgP-Ger; 680 cases vs 3,973 controls) and the CARDIoGRAMplusC4D CAD meta-analysis dataset (60,801 cases vs 123,504 controls). Two SNPs at the known CAD risk loci ADAMTS7 (rs11634042) and VAMP8 (rs1561198) passed the pre-assigned selection criteria (P AgP-Ger  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-31980-8